ISSN 2149-2247 | E-ISSN 2149-2549
Original Article
Beneficial Effects of Quercetin on the Zone of Stasis in an Experimental Burn Model
1 Department of Plastic Surgery, Namik Kemal University, Faculty of Medicine, Tekirdağ, Turkey  
2 Department of Nuclear Medicine, Gaziantep University, Faculty of Medicine, Gaziantep, Turkey  
3 Department of Histology and Embryology, Trakya University, Faculty of Medicine, Edirne, Turkey  
Erciyes Med J 2018; 40: 125-130
DOI: 10.5152/etd.2017.0164
Key Words: Zone of stasis, quercetin, apoptosis, autophagy
Abstract

Objective: In burn injury, the zone of stasis determines the width and depth of the necrosis. Our aim is to show the effectiveness of quercetin on the viability within the zone of stasis in burns of rats.


Materials and Methods
: Forty-eight rats were divided into three groups. The rats in Group 1 (control group) were only applied the comb burn model; the rats in Group 2 (post-burn group) were administered 50 mg/kg of quercetin intraperitoneally, every day after the burn procedure until euthanasia; and the rats in Group 3 (pre-burn group) were administered 50 mg/kg of quercetin intraperitoneally, every day for 7 days before and after the burn procedure until euthanasia.


Results
: The living tissue calculated was 85.41% (±14.06) in Group 3, 40.37% (±9.75) in Group 2, and 16.81% (±9.4) in Group 1. The level of apoptosis was 30.0 (±10.8) in Group 3, 33.8 (±08.7) in Group 2, and 37.4 (±11.5) in Group 1. The level of autophagy was 49.50 (±8.58) in Group 3, 27.17 (±5.53) in Group 2, and 21.00 (±5.66) in Group 1. All the differences between the groups were statistically significant (p<0.01).


Conclusion
: Quercetin reduces apoptosis and increases autophagy, thereby increasing tissue viability in the zone of stasis of burn injury.


Cite this article as
: Orhan E, Şahin E, Sapmaz-Metin M, Topçu-Tarladaçalışır Y. Beneficial effects of Quercetin on the zone of stasis in an experimental burn model. Erciyes Med J 2018; 40(3): 125-30.


 

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