ISSN 2149-2247 | E-ISSN 2149-2549
Original Article
Evaluation of Oxidative Stress and Thiol-Disulfide Parameters According to the Body Mass Index in Adult Individuals
1 İstanbul Bilim University, Vocational Faculty of Health Services, İstanbul, Turkey  
2 Department of Clinical Biochemistry, Yıldırım Beyazıt University, Faculty of Medicine, Ankara, Turkey  
3 Clinic of Internal Medicine, Eyüp State Hospital, İstanbul, Turkey  
4 Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden  
Erciyes Med J 2018; 40: 155-161
DOI: 10.5152/etd.2018.0059
Key Words: IMA, TAS, thiol-disulfide homeostasis, TOS, ceruloplasmin
Abstract

Objective: In this study, the parameters of oxidative stress markers and thiol–disulfide homeostasis as a novel biomarker were evaluated in experimental groups of adult individuals, which were formed according to the body mass index (BMI).


Materials and Methods
: A total of 165 adult patients were grouped as normal weight (BMI 18.5–24.9, n=39), pre-obese or overweight (BMI 25–29.9, n=47), obese (BMI 30–34.9; n=44), and severely obese (BMI >35, n=35). In addition to thiol–disulfide homeostasis parameters, the total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), ischemia-modified albumin (IMA), albumin, and ceruloplasmin levels were determined.


Results
: Native thiol, total thiol, and native thiol/total thiol % levels were significantly decreased in the overweight, obese, and severely obese groups compared to the normal weight group (p<0.001). Disulfide levels were elevated in the overweight group compared to the normal weight group (p<0.01). While the TOS and OSI levels of the normal weight group were elevated compared to the overweight (p<0.001) and obese/severely obese groups (p<0.05), albumin levels of the normal weight group were reduced compared to other groups (p<0.001). The IMA levels of the overweight group were elevated compared to the normal weight and severely obese groups (p<0.05 and p<0.001, respectively). Ceruloplasmin levels of the severely obese group were increased compared to the normal weight and overweight groups (p<0.001 and p<0.01, respectively).


Conclusion
: In our study, oxidative stress was increased in groups with a BMI greater than normal (≥25). In addition to this, the oxidative stress and thiol–disulfide homeostasis markers are observed to be further increased in the overweight group than the obese (≥30) group due to body’s reaction to first inconsistency.


Cite this article as
: Söğüt İ, Şenat Aydın A, Sağlam Gökmen E, Gün Atak P, Erel Ö, Görmüş DeGrigo U. Evaluation of oxidative stress and thiol/ disulfide parameters according to BMI in adult individuals. Erciyes Med J 2018; 40(3): 155-61.

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