ISSN 2149-2247 | E-ISSN 2149-2549
Original Article
Treatment Outcomes of Postmenopausal Osteoporosis in Patıents with Stable Hypothyroidism: A 5 Year Follow Up Retrospective Study
1 Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey  
Erciyes Med J ; : -
DOI: 10.5152/etd.2018.0065
Key Words: Hypothyroidism, postmenopausal, osteoporosis, bone, quality
Abstract

Objective: The aim of this study is to evaluate the efficacy of hypothyroidism on the treatment outcomes of postmenopausal osteoporosis (PMOP) treatment. 



Materials and Methods
: 50 patients with hypothyroidism and also diagnosed as PMOP according to lumbar and femur neck bone mass density (BMD) evaluation with dual X-ray absorptiometry (DXA) who did not receive any treatment for PMOP including calcium and vitamin D were included for the study. Control group was constituted by 47 patients with PMOP but have no comorbidity. Demographic features including age, height, weight, occupation, level of education, menarche and menopause age, clothing style, daily calcium intake, tobacco and/or alcohol consumption, daily physical activity level, personal history of fragility fracture or in mother and duration of hypothyroidism were recorded. Biochemical parameters including BMD scores, calcium, phosphate, alkaline phosphatase, parathormone, calcidiol, osteocalcine, urine calcium, phosphate levels and creatinine clearance were also recorded. Patients were treated with bisphosphonate, calcium and vitamin D and same parameters were evaluated at the end of first and fifth year. 


Results
: The average age of all individuals was 58.25±8.89 years and the average duration of hypothyroidism diagnosis was 4.00 years. The demographic features and biochemical parameters before PMOP treatment were not different between patient and control groups (p>0,005). BMD scores of both groups were significantly improved at the end of first and fifth years of treatment (p<0,005) but the variation of the scores were not different. 


Conclusions
: Hypothyroidism with stable or unstable thyroid functions does not effect PMOP treatment prognısis in Turkish population. 


Cite this article as
: Yılmaz V, Umay E, Gündoğdu İ, Tezel N. Treatment Outcomes of Postmenopausal Osteoporosis in Patıents with Stable Hypothyroidism: A 5 Year Follow Up Retrospective Study. Erciyes Med J 2018; DOI: 10.5152/etd.2018.0065

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