ISSN: 2149-2247 | E-ISSN: 2149-2549

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Efficacy of N-acetyl Cysteine in Patients with Dyspepsia with Negative Helicobacter pylori Infection [Erciyes Med J]
Erciyes Med J. 2019; 41(2): 153-157 | DOI: 10.14744/etd.2019.34445

Efficacy of N-acetyl Cysteine in Patients with Dyspepsia with Negative Helicobacter pylori Infection

Naser Hajavi1, Khatereh Isazadeh Far2, Moharram Eslami1, Afshin Habibzadeh1, Mehdi Hemmati3, Crystal Lu4
1Department of Internal Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
2Social Determinants of Health Research Center (SDH), Ardabil University of Medical Sciences, Ardabil, Iran
3Department of Medicine, Medstar Health (Baltimore)/Medstar Georgetown University Hospital, Washington, District of Columbia, USA
4University of Maryland Medical Center, Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA

Objective: In this study, we evaluated the efficacy of NAC in dyspepsia symptoms in Helicobacter pylori (H. pylori) negative dyspeptic patients.
Materials and Methods: In this randomized clinical trial, 85 patients with functional dyspepsia without H. pylori infection underwent treatment with a proton pump inhibitor (PPI) pantoprazole 40mg daily (n=41) with or without NAC 600mg twice a day (n=44) for 8 weeks. Patients’ clinical symptoms and change in the severity of dyspepsia symptoms were compared between the groups.
Results: Common symptoms were epigastric pain and bloating. The intervention group had significantly more cases with retrosternal burn and bloating and less early satiety as compared to the control group. In both intervention and control groups dyspepsia severity was significantly reduced from 5.26±2.06 and 4.68±2.81 to 1.87±1.38 and 2.22±2.04, respectively (p<0.001). The percent of reduction in dyspepsia severity in intervention group was significantly higher than control group (-66.25±23.44% vs. -50.14±35.02%, p=0.01).
Conclusion: PPI is an effective treatment for functional dyspepsia and NAC as an adjuvant to a PPI is a safe medication that can increase the response rate and treatment efficacy.

Keywords: Functional dyspepsia, N-acetyl cysteine, Proton pump inhibitor

Naser Hajavi, Khatereh Isazadeh Far, Moharram Eslami, Afshin Habibzadeh, Mehdi Hemmati, Crystal Lu. Efficacy of N-acetyl Cysteine in Patients with Dyspepsia with Negative Helicobacter pylori Infection. Erciyes Med J. 2019; 41(2): 153-157

Corresponding Author: Moharram Eslami, Iran
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