ISSN: 2149-2247 | E-ISSN: 2149-2549

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Febuxostat Mitigates Genotoxicity Induced by Ionizing Radiation in Human Normal Lymphocytes [Erciyes Med J]
Erciyes Med J. Ahead of Print: EMJ-35762 | DOI: 10.14744/etd.2019.35762

Febuxostat Mitigates Genotoxicity Induced by Ionizing Radiation in Human Normal Lymphocytes

Shiva Asemi1, Arash Ghasemi3, Seyed Jalal Hosseinimehr2
1Department of Radiopharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran; Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran
2Department of Radiopharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
3Department of Radiology and Radiation Oncology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

Febuxostat (BF) is a xanthine oxidase inhibitor that has been usedto treat chronic gout. FBexhibits anti-inflammatory effect. In this study, the radioprotective effect of BF was investigated against genotoxicity induced by ionizing radiation (IR) in human healthy lymphocytes.Peripheral blood samples were treated with BF at various concentrations for three hours. Then, the whole blood samples were exposed to IR at a dose of 1.5 Gy. Lymphocytes were cultured for determining the frequency of micronuclei in binucleated lymphocytes.The frequency of micronuclei was significantly decreased in human lymphocytes which were exposed to IR and treated with BF as compared to irradiated lymphocytes without BF treatment. The maximum radioprotection as decreasing in the frequency of micronuclei was observed at 100 μM of BF treatment (43% decrease). The anti-inflammatory property is probably involved in the mechanism of FB exerting radioprotective effect in human lymphocytes.

Keywords: Febuxostat, DNA damage, radioprotective, micronucleus test, radiation biology



Corresponding Author: Seyed Jalal Hosseinimehr, Iran
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