ISSN: 2149-2247 | E-ISSN: 2149-2549

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Investigation of the Methylenetetrahydrofolate Reductase Gene C677T and A1298G Polymorphism in Chronic Periodontitis [Erciyes Med J]
Erciyes Med J. 2019; 41(3): 250-254 | DOI: 10.14744/etd.2019.39259

Investigation of the Methylenetetrahydrofolate Reductase Gene C677T and A1298G Polymorphism in Chronic Periodontitis

Gülhan Kocaman1, Recep Orbak2
1Department of Periodontology, Karabük University, Faculty of Dentistry, Karabük, Turkey
2Department of Periodontology, Atatürk University Faculty of Dentistry, Erzurum, Turkey

Objective: This case control study examined the frequency and distribution of the C677T and A1298C single-nucleotide polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene in Turkish patients with chronic periodontitis.
Materials and Methods: This study included 89 subjects: 49 patients with chronic periodontitis and 40 healthy persons. Medical and periodontal histories were taken, and PD, CAL, PI, and BOP were recorded as the clinical parameters. The blood samples were taken from the subjects, and their DNA was obtained. The MTHFR gene’s single nucleotide polymorphisms 677C→T and 1298A→C genotyping were analyzed using the RFLP assay, then PCR.
Results: There was a significant difference between the groups except for age when the clinical findings. Single-nucleotide polymorphisms in the MTHFR gene C677T and 1298C regions were not found to be significantly different between the groups.
Conclusion: The study revealed no association between the MTHFR polymorphism and the risk of chronic periodontitis; however, increasing the number of patients is useful when performing further studies. This present study is important because it is, to the best of our knowledge, the first study to research the interrelation between the MTHFR gene and chronic periodontitis.

Keywords: Methylenetetrahydrofolate reductase (MTHFR), polymorphisms, periodontitis.

Gülhan Kocaman, Recep Orbak. Investigation of the Methylenetetrahydrofolate Reductase Gene C677T and A1298G Polymorphism in Chronic Periodontitis. Erciyes Med J. 2019; 41(3): 250-254

Corresponding Author: Gülhan Kocaman, Türkiye
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