ISSN: 2149-2247 | E-ISSN: 2149-2549
Diagnostic Efficacy of Signal Intensity Ratio and Apparent Diffusion Coefficient Measurements in Differentiating Cerebellopontine Angle Meningioma and Schwannoma [Erciyes Med J]
Erciyes Med J. 2020; 42(3): 281-288 | DOI: 10.14744/etd.2020.61580

Diagnostic Efficacy of Signal Intensity Ratio and Apparent Diffusion Coefficient Measurements in Differentiating Cerebellopontine Angle Meningioma and Schwannoma

Mustafa Bozdağ1, Ali Er1, Sümeyye Ekmekçi2
1Department of Radiology, TR Ministry of Health İzmir Tepecik Training and Research Hospital, İzmir, Turkey
2Department of Pathology, TR Ministry of Health İzmir Tepecik Training and Research Hospital, İzmir, Turkey

Objective: To investigate the efficacy of Signal Intensity Ratio (SIR) measurements of T2-weighted imaging (T2WI) and Apparent Diffusion Coefficient (ADC) values of ADC mapping in the differentiation of schwannomas and meningiomas originating from the CPA.
Materials and Methods: A total of 30 patients who were pathologically diagnosed (16 meningiomas, 14 VS) were included in this retrospective study. SIR was calculated by proportioning regions of interests (ROIs) measurements of solid regions of the tumor and occipital subcutaneous adipose tissue in T2WI. In ADC maps, ADCmin and ADCmean values were obtained by placing ROIs inside the solid parts of the tumor. Groups were statistically analyzed using the Mann-Whitney U test, independent-sample t-test, receiver operating characteristic (ROC) curve analyses, and Pearson correlation test.
Results: SIR, ADCmean, and ADCmin values were 0.61±0.08, 0.858±0.101x10–3 mm2/s, 0.815±0.099x10–3 mm2/s for meningioma group; and 0.80±0.12, 1.272±0.148x10–3 mm2/s, 1.232±0.148x10–3 mm2/s for VS group, respectively. These parameters were statistically lower in the meningioma group compared to the VS group (p<0.001 for all). A positive correlation was observed between SIR and ADC values among the total group (r=0.694, p<0.001 for both). ROC analysis showed that the diagnostic performance of ADC parameters was better than the SIR parameter in differentiating meningioma from VS. The cut-off values in differentiating meningioma and VS were determined as 1.027x10–3 mm2/s for ADCmean and 0.980x10–3 mm2/s for ADCmin with 100% sensitivity.
Conclusion: While both ADC and SIR values are useful in differentiating between VS and meningioma, ADC values have higher diagnostic efficacy compared to SIR.

Keywords: Apparent diffusion coefficient, signal intensity ratio, cerebellopontine angle, meningioma, schwannoma

Mustafa Bozdağ, Ali Er, Sümeyye Ekmekçi. Diagnostic Efficacy of Signal Intensity Ratio and Apparent Diffusion Coefficient Measurements in Differentiating Cerebellopontine Angle Meningioma and Schwannoma. Erciyes Med J. 2020; 42(3): 281-288

Corresponding Author: Ali Er, Türkiye
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