ISSN: 2149-2247 | E-ISSN: 2149-2549
Evaluation of Serum Levels of Renin Angiotensin System Components in Asthmatic Patients [Erciyes Med J]
Erciyes Med J. 2015; 37(3): 87-90 | DOI: 10.5152/etd.2015.0027

Evaluation of Serum Levels of Renin Angiotensin System Components in Asthmatic Patients

Ceylan Ayada1, Ümran Toru2, Osman Genç1, Server Şahin3, İsmet Bulut4, Özlem Arık5, Murat Acat6
1Department of Physiology, Dumlupınar University Faculty of Medicine, Kütahya, Turkey
2Department of Thoracic Medicine, Dumlupınar University Faculty of Medicine, Kütahya, Turkey
3Department of Medical Biology, Dumlupınar University Faculty of Medicine, Kütahya, Turkey
4Clinic of Adult Immunology and Allergy, Süreyyapaşa Chest Diseases and Thoracic Surgery Training and Research Hospital, İstanbul, Turkey
5Department of Biostatistic, Dumlupınar University, Faculty of Medicine, Kütahya, Turkey
6Aydın General Secretary of the Union of Public Hospitals, Aydın, Turkey

Objective: Asthma is a chronic inflammatory lung disease. The renin–angiotensin system (RAS) targets several tissues and maintains fluid homeostasis. It is also known that RAS plays a role in inflammatory processes. Angiotensin-converting enzyme (ACE) and its product angiotensin II (AngII), which are the components of RAS, regulate the known effects of RAS. The other components of RAS, ACE2 and its product Ang 1–7, regulate the counter-effects of RAS. That is why the activation or inhibition of RAS can offer new therapeutic strategies for treating several diseases. We aimed to investigate the serum level of RAS components such as angiotensinogen (AGT), ACE, AngII, ACE2, and Ang 1–7 in asthma and control groups.
Materials and Methods: This study was performed on 27 asthma and 23 healthy individuals. The serum levels of AGT, ACE, AngII, ACE2, and Ang 1–7 were measured by human enzyme-linked immunosorbent assay (ELISA) kits.
Results: There were no statistically significant differences for the serum levels of AGT and ACE between the groups. The serum levels of AngII, ACE2, and Ang 1–7 were significanlty higher in the asthma group than those in the control group.
Conclusion: Our results indicate that two tails of RAS, i.e., the ACE and ACE2 pathways, are activated in asthma compared to are activated more in the asthma group than in the control group. We suppose that the activation of ACE2 tail of RAS occurs because of the homeostatic balance requirements of this system. We believe that the activation of ACE2 pathway, in addition to the inhibition of the ACE pathway, can provide clinical benefits in treating asthma.

Keywords: Angiotensinogen (ANG), Angiotensin II (AngII), Angiotensin-converting Enzyme (ACE), ACE2, Ang 1–7

Ceylan Ayada, Ümran Toru, Osman Genç, Server Şahin, İsmet Bulut, Özlem Arık, Murat Acat. Evaluation of Serum Levels of Renin Angiotensin System Components in Asthmatic Patients. Erciyes Med J. 2015; 37(3): 87-90

Corresponding Author: Ceylan Ayada, Türkiye
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