ISSN: 2149-2247 | E-ISSN: 2149-2549

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Colorectal Cancer in Patients Aged ≤30 Years: 17 Years of Experience [Erciyes Med J]
Erciyes Med J. 2019; 41(1): 62-68 | DOI: 10.14744/etd.2018.18109

Colorectal Cancer in Patients Aged ≤30 Years: 17 Years of Experience

Şükrü Özaydın1, Erman Ataş2, Mustafa Tanrıseven3, Muhammet A. Kaplan4, Patrick Hartendorp5, Aytekin Ünlü3, Patrizio Petrone5, Nuri Karadurmuş1, Fikret Arpacı1
1Department of Medical Oncology, Gülhane Training and Research Hospital, Ankara, Turkey
2Department of Paediatric Oncolog, Gülhane Training and Research Hospital, Ankara, Turkey
3Department of General Surgery, Gülhane Training and Research Hospital, Ankara, Turkey
4Department of Medical Oncology, Dicle University Faculty of Medicine, Diyarbakır, Turkey
5Department of Surgery, NYU Winthrop Hospital, Mineola, New York, USA

Objective: Although its incidence has been increasing, colorectal cancer is rare in young patients. There are conflicting reports on its prognosis in young patients with colorectal cancers. The goal of this study is to investigate the prognostic factors in young patients with colorectal cancer. An observational, population-based, retrospective study.
Materials and Methods: The clinicopathological characteristics, treatment approaches, and survival data of patients with colorectal cancers aged 30 years and younger were retrospectively analyzed.
Results: A total of 32 patients were identified. Hematochezia and abdominal pain were the major signs of colorectal cancer. Left-sided tumors (rectum 53.1%, and left colon 25%) were found to be more common than right-sided (18.8%) and transverse colon tumors (3.1%). Curative surgery was performed in 81.3% of patients. Histologically, 43.8% of cancers found were poorly differentiated. According to the subtype, 21.9% were signet ring cell, and 25% were mucinous (colloid) tumors. Patients were evaluated as Stage III in 46.9% and Stage IV in 31.3% of cases. The 3-year progression-free survival (PFS) was 38.7%, and the 3-year overall survival (OS) was 53.2%. Stage IV disease and disease without curative surgery were poor prognostic factors, both for the OS and PFS.
Conclusion: Prognosis was poor in young patients with colorectal cancer. In this institutional study, an advanced stage, left-sided localization, and poor histological feature were frequently detected. The stage and complete surgery were predictive factors for the long-term survival. In this respect, it is important for physicians to heighten their awareness of the increased incidence of colon cancer in younger patients.

Keywords: Colorectal cancer, young patients, demographics, prognosis

Şükrü Özaydın, Erman Ataş, Mustafa Tanrıseven, Muhammet A. Kaplan, Patrick Hartendorp, Aytekin Ünlü, Patrizio Petrone, Nuri Karadurmuş, Fikret Arpacı. Colorectal Cancer in Patients Aged ≤30 Years: 17 Years of Experience. Erciyes Med J. 2019; 41(1): 62-68

Corresponding Author: Şükrü Özaydın, Türkiye
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