ISSN: 2149-2247 | E-ISSN: 2149-2549

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Erciyes Medical Journal Pre- and Postoperative Evaluation of the Effect of Atrial Septal Defect on Systemic Circulation Via Pulse Wave Velocity [Erciyes Med J]
Erciyes Med J. 2019; 41(3): 321-326 | DOI: 10.14744/etd.2019.06888

Pre- and Postoperative Evaluation of the Effect of Atrial Septal Defect on Systemic Circulation Via Pulse Wave Velocity

Şaban Keleşoğlu1, Deniz Elcik2, Aydın Tunçay3, Ali Doğan2, Mustafa Fehmi Bireciklioğlu2, Zeki Çetinkaya2, Mehmet Tuğrul Inanç2, Nihat Kalay2, Ramazan Topsakal2, Abdurrahman Oğuzhan2
1Department of Cardiology, Kayseri Training and Research Hospital, Kayseri, Turkey
2Department of Cardiology, Erciyes University Faculty of Medicine, Kayseri, Turkey
3Department of Cardiolovasculer Surgery, Erciyes University Faculty of Medicine, Kayseri, Turkey

Objective: The aim of the present study was to examine whether endothelial function is affected in patients with atrial septal defect (ASD) of secundum type and to determine the changes that might occur in endothelial function after the defect was closed by the transcatheter method by using the pulse wave velocity (PWV) technique.
Materials and Methods: A total of 54 patients with ASD type and 40 healthy individuals were included in the study. All patients underwent transthoracic echocardiography and PWV measurements to evaluate the endothelial function prior to and 1 month after the closure procedure.
Results: PWV values were significantly higher in patients with ASD than in healthy subjects (7.5±1.2 m/s vs. 6.1±1.0 m/s, p<0.001). Systolic pulmonary arterial pressure (PAP), right ventricular diameter, and PWV values were significantly lower at 1 month of follow-up after the procedure than at baseline (p<0.001). However left ventricular ejection fraction, left ventricular end-diastolic diameter (LVEDD), and tricuspid annular plane systolic excursion values increased significantly after the procedure component (p<0.001, p=0.002, and p<0.001, respectively).
Conclusion: It was observed that following closure of the ASD by the transcatheter route, the PWV values were significantly reduced in the right cardiac chambers, and the systolic PAP was improved. This result has shown us that ASD closure may benefit from endothelial dysfunction.

Keywords: Atrial septal defect, endothelial dysfunction, pulse wave velocity.

Şaban Keleşoğlu, Deniz Elcik, Aydın Tunçay, Ali Doğan, Mustafa Fehmi Bireciklioğlu, Zeki Çetinkaya, Mehmet Tuğrul Inanç, Nihat Kalay, Ramazan Topsakal, Abdurrahman Oğuzhan. Pre- and Postoperative Evaluation of the Effect of Atrial Septal Defect on Systemic Circulation Via Pulse Wave Velocity. Erciyes Med J. 2019; 41(3): 321-326

Corresponding Author: Deniz Elcik, Türkiye
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