Objective: Continuous renal replacement therapy is made with high biocompatibility membranes that have high current power by using diffusion and convection together or seperately. We aimed to compare EMIC-2 and AV600S filters used for continuous venovenous hemodiafiltration (CVVHDF) in terms of the effects on sepsis, elimination of toxins that are elevated due to acute renal injury and the effects on inflammatory mediators in severe sepsis.
Methods: The study is about 38 patients who were diagnosed with severe sepsis and were treated with hemodiafiltration in intensive care unit. APACHE-2 (Acute Physiology, Age, Chronic Health Evaluation-2) and SOFA scores (Sequential Organ Failure Assesment Scores) of the patients were calculated before CVVHDF starts. Hematocrit, white blood cell, blood pressure, heart rate and body temperature values were measured and recorded. Procalcitonin (PCT), tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6), interleukin-1 (IL-1) values on blood were also recorded before the process and on 8th, 16th and 24th hours of the process.
Results: When AV600S filtered and EMIC-2 filtered groups are compared; TNF-α values are low in EMIC-2 filtered group (p<0.05). There is no significant difference between the groups in terms of the measurements about APACHE-2, SOFA, IL-1β, IL-6, PCT, hematocrit, body temperature, mean blood pressures and heart rate.
Conclusion: We think that the filters dont cause a significant change on elimination of inflammatory cytokines, except TNF-α, on limited numbers of patients that have sepsis with acute renal injury are taking CVVHDF with EMIC-2 and AV600S.