ISSN: 2149-2247 | E-ISSN: 2149-2549

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Erciyes Medical Journal Comparison of the Performance of Second (Fast TSH) and Third (HYPERsensitive TSH) Generation Automated TSH Immunoassays in Healthy Euthyroid Subjects [Erciyes Med J]
Erciyes Med J. 2019; 41(1): 46-49 | DOI: 10.14744/etd.2018.18127

Comparison of the Performance of Second (Fast TSH) and Third (HYPERsensitive TSH) Generation Automated TSH Immunoassays in Healthy Euthyroid Subjects

Esin Çalcı1, Halef Okan Doğan2, Fatma Sağlam3, Turan Turhan4, Dilek Berker5
1Department of Biochemistry, Uşak Public Health Laboratory, Uşak, Turkey
2Department of Biochemistry, Cumhuriyet University Faculty of Medicine, Sivas, Turkey
3Department of Endocrinology, Etimed Hospital, Ankara, Turkey
4Department of Biochemistry, Ankara Numune Education and Research Hospital, Ankara, Turkey
5Department of Endocrinology, Ankara Numune Education and Research Hospital, Ankara, Turkey

Objective: We aimed to compare the performances of HYPERsensitive and Fast thyroid-stimulating hormone (TSH) methods in euthyroid subjects.
Materials and Methods: The study included 500 euthyroid subjects. We measured the TSH levels of study subjects using HYPERsensitive and Fast TSH methods. We compared the performances of the two methods. Moreover, free triiodothyronine and thyroxine, anti-thyroglobulin, and anti-thyroperoxidase levels were determined in study subjects.
Results: Mean serum TSH levels were determined as 1.76±1.06 and 1.85±1.12 µIU/mL using Fast and HYPERsensitive TSH methods, respectively. Differences were statistically significant (p<0.05). We found a positive correlation between Fast and HYPERsensitive TSH methods (r=0.960, p<0.001).
Conclusion: Although the sensitivity and precision of HYPERsensitive TSH method is better than that of Fast TSH method, the Fast TSH method needs lower sample volume, and the reaction time is shorter than that in HYPERsensitive TSH method. Thus, clinical biochemistry laboratories should select an appropriate method according to their requirements.

Keywords: Fast TSH, HYPERsensitive TSH, method comparison, generation

Esin Çalcı, Halef Okan Doğan, Fatma Sağlam, Turan Turhan, Dilek Berker. Comparison of the Performance of Second (Fast TSH) and Third (HYPERsensitive TSH) Generation Automated TSH Immunoassays in Healthy Euthyroid Subjects. Erciyes Med J. 2019; 41(1): 46-49

Corresponding Author: Esin Çalcı
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