ISSN: 2149-2247 | E-ISSN: 2149-2549

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Erciyes Medical Journal Effects of Triclosan-Impregnated Suture Materials on Colonic Anastomosis [Erciyes Med J]
Erciyes Med J. 2020; 42(1): 12-17 | DOI: 10.14744/etd.2019.70973

Effects of Triclosan-Impregnated Suture Materials on Colonic Anastomosis

Mustafa Atabey1, Ayça Taş2, Ömer Topçu3, Yavuz Silig4
1Department of General Surgery, Biruni University, Faculty of Medicine, Istanbul, Turkey
2Department of Nutrition and Diet, Cumhuriyet University Faculty of Health Sciences, Sivas, Turkey
3Department of General Surgery, Sivas Cumhuriyet University Faculty of Medicine, Sivas, Turkey
4Department of Biochemistry, Cumhuriyet University Faculty of Medicine, Sivas, Turkey

Objective: Symptomatic anastomotic leakage observed after colorectal surgery is one of the major complications. One of the factors affecting the anastomosis healing is the type of suture material used. This study aims to investigate the effects of the suture material polydioxanone (PDS, Ethicon), which is late absorbable and has a monofilament structure, and the suture material polyglactin 910 (Vicryl, Ethicon), which is absorbable and has a multifilament structure, on the healing of colonic anastomosis, and to compare the traditional forms of these sutures with their antibacterial effective triclosan-impregnated forms (PDS Plus, Ethicon and Vicryl Plus, Ethicon).
Materials and Methods: The rats were divided into four equal groups consisting of 10 subjects each: Group I: Vicryl; Group II: Vicryl Plus; Group III: PDS; and Group IV: PDS Plus. The presence of wound infection, whether the integrity of the abdominal wall was maintained, intra-abdominal adhesion scoring, the presence of intra-abdominal abscess, and whether the macroscopic integrity of anastomosis was maintained were evaluated.
Results: According to the results of this experimental study, while the highest ABP and hydroxyproline levels were observed in the PDS Plus group, the lowest values were observed in the Vicryl group. However, the difference was not statistically significant.
Conclusion: Slowly absorbable and monofilament PDS suture material causes less tissue reaction and inflammatory response compared to the Vicryl suture material that is absorbable in the colonic anastomosis line and multifilament.

Keywords: Polydioxanone, polyglactin 910, triclosan, colonic anastomosis, hydroxyproline.

Mustafa Atabey, Ayça Taş, Ömer Topçu, Yavuz Silig. Effects of Triclosan-Impregnated Suture Materials on Colonic Anastomosis. Erciyes Med J. 2020; 42(1): 12-17

Corresponding Author: Ayça Taş, Türkiye
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