ISSN: 2149-2247 | E-ISSN: 2149-2549

Quick Search




Erciyes Medical Journal Role of Cytology in Pleural Effusion: A Single-Center Experience [Erciyes Med J]
Erciyes Med J. 2019; 41(4): 409-413 | DOI: 10.14744/etd.2019.88557

Role of Cytology in Pleural Effusion: A Single-Center Experience

Canan Sadullahoğlu1, Ruşen Uzun2
1Department of Pathology, Health Sciences University, Antalya Training and Research Hospital, Antalya, Turkey
2Department of Pulmonology, Health Sciences University, Antalya Training and Research Hospital, Antalya, Turkey

Objective: As a fast and effective method, cytopathological examination of the pleural fluid is the diagnostic tool of choice in determining the etiology of a spectrum of inflammatory to neoplastic conditions. The aim of the present study was to investigate the role of pleural cytology samples examined within a certain time period in determining the presence of malignant cells.
Materials and Methods: Cytological materials of 433 patients with pleural effusion (PE) were retrospectively analyzed. Clinical parameters and cytological diagnosis were recorded in consecutive patients with PE.
Results: Of the 433 cases enrolled in the study, 264 (61%) were male, and 169 (39%) were female. 15.6% (67/433) of the cases were reported as malignant, and 85% were aged >50 years. It was found that the contribution of repeated cytological examination of a material to diagnosis was approximately 3%. The sensitivity and specificity of the cytological method were calculated as 34% and 99%, respectively. Immunocytochemistry was performed in 50 patients who received cell-block techniques, and 42.4% of those were diagnosed as malignant. Molecular tests were also performed in 5 patients.
Conclusion: Although the sensitivity is low, cytological examination of the pleura can be considered a diagnostic tool of vital importance, especially in patients with an advanced-stage disease and poor performance, who can benefit from rapidly evolving and changing treatment options.

Keywords: Immunocytochemistry, molecular targeted therapy, malignant pleural effusion.

Canan Sadullahoğlu, Ruşen Uzun. Role of Cytology in Pleural Effusion: A Single-Center Experience. Erciyes Med J. 2019; 41(4): 409-413

Corresponding Author: Canan Sadullahoğlu, Türkiye
LookUs & Online Makale