ISSN: 2149-2247 | E-ISSN: 2149-2549
The effect of Blood Urea Nitrogen/Albumin Ratio in the Short-Term Prognosis of Chronic Obstructive Pulmonary Disease [Erciyes Med J]
Erciyes Med J. 2021; 43(2): 184-188 | DOI: 10.14744/etd.2020.13914

The effect of Blood Urea Nitrogen/Albumin Ratio in the Short-Term Prognosis of Chronic Obstructive Pulmonary Disease

Ayşe Demir Baha1, Türkan Zeynep Işıkdoğan Fendoğlu2, Nurdan Köktürk3, Hatice Kılıç4, Hatice Canan Hasanoğlu4, Sertaç Arslan5, Meral Gülhan5, Nalan Ogan6, Evrim Eylem Akpınar7, Aslıhan Alhan8
1Department of Chest Diseases, Near East University Faculty of Medicine, Lefkoşa, Cyprus
2Department of Chest Diseases, Beytepe Murat Erdi Eker National Hospital, Ankara, Turkey
3Department of Chest Diseases, Gazi University Faculty of Medicine, Ankara, Turkey
4Department of Chest Diseases, Ankara Atatürk Training and Research Hospital, Ankara, Turkey
5Department of Chest Diseases, Hitit University Faculty of Medicine, Çorum, Turkey
6Department of Chest Diseases, Ufuk University Faculty of Medicine, Ankara, Turkey
7Ufuk University Faculty of Medicine, Ankara, Turkey
8Department of Biostatistics, Ufuk University Doctor Rıdvan Ege Training and Research Hospital, Ankara, Turkey

Objective: There is no definite laboratory parameter in predicting short-term prognosis in patients with chronic obstructive pulmonary disease (COPD). Our aim was to evaluate the prognostic effect of serum blood urea nitrogen (BUN)/albumin ratio in COPD patients.
Materials and Methods: A retrospective study comprising of 264 COPD patients who were in exacerbation period and selected from 4 centers was carried out. Data on demographic characteristics, disease characteristics, comorbid conditions and short-term prognosis of patients were obtained. and analyzed.
Results: The BUN/Albumin ratio was higher in patients with oxygen saturation <90% (p=0.004). There was no difference between global obstructive lung disease (GOLD) stages means of BUN/Albumin ratio but this rate was higher in those with infective exacerbations (p=0.019). The BUN/albumin ratio of patients who were discharged (5.3±2.2) was significantly higher than the patients who were transferred to the intensive care unit [ICU] (11.7±6.0) (p<0.0001). The cut-off level of BUN/albumin ratio in prediction of the need for ICU was7.2 (sensitivity 80%, specificity 85.4%) and the area under the receiver operating characteristic (ROC) curve was 0.911 (95% CI: 0.861–0.961) (p<0.001). The cut-off level of BUN/albumin ratio in prediction of mortality was 8.1 (sensitivity 88.2%, specificity 85.4%) and the area under the ROC curve was 0.963 (95% CI: 0.930–0.995) (p<0.001).
Conclusion: BUN/albumin ratio can be used as an affordable, inexpensive and practical method for determining the short-term prognosis in hospitalized COPD patients. Prospective studies involving more patients are needed.

Keywords: COPD, biomarker, BUN/albumin ratio, prognosis, mortality.

Ayşe Demir Baha, Türkan Zeynep Işıkdoğan Fendoğlu, Nurdan Köktürk, Hatice Kılıç, Hatice Canan Hasanoğlu, Sertaç Arslan, Meral Gülhan, Nalan Ogan, Evrim Eylem Akpınar, Aslıhan Alhan. The effect of Blood Urea Nitrogen/Albumin Ratio in the Short-Term Prognosis of Chronic Obstructive Pulmonary Disease. Erciyes Med J. 2021; 43(2): 184-188

Corresponding Author: Ayşe Demir Baha, Cyprus
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