ISSN: 2149-2247 | E-ISSN: 2149-2549
Relationship Between the Flow-Mediated Dilatation of the Human Brachial Artery and Blood Biomarkers Related to the Endothelial Function in Cardiovascular Diseases [Erciyes Med J]
Erciyes Med J. 2021; 43(1): 75-82 | DOI: 10.14744/etd.2020.90592

Relationship Between the Flow-Mediated Dilatation of the Human Brachial Artery and Blood Biomarkers Related to the Endothelial Function in Cardiovascular Diseases

Suzan Emel Usanmaz1, Inci Asli Atar2, Ayşen Aksöyek3, Muharrem Tola4, Emre Kubat5, Tugba Kayhan Altuner6, Hüseyin Bozbaş6, Utkan Sevuk7, Mehmet Emin Korkmaz6, Emine Demirel-Yilmaz1
1Department of Medical Pharmacology, Ankara University Faculty of Medicine, Ankara, Turkey
2Department of Cardiology, Ministry of Health Ankara City Hospital, Ankara, Turkey
3Department of Cardiovascular Surgery, Ministry of Health Ankara City Hospital, Ankara, Turkey
4Department of Radiology, Ministry of Health Ankara City Hospital, Ankara, Turkey
5Department of Cardiovascular Surgery, Gülhane Training and Research Hospital, Ankara, Turkey
6Department of Cardiology, Güven Hospital, Ankara, Turkey
7Department of Cardiovascular Surgery, Dicle University Faculty of Medicine, Diyarbakır, Turkey

Objective: Endothelial dysfunction plays an important role in the development of heart diseases. Although several markers have been examined, a definitive biomarker for monitoring endothelial function has not yet been established. The flow-mediated dilatation (FMD) of the brachial artery enables non-invasive assessment of endothelial function. This study investigated plasma levels of nitric oxide (NO), asymmetric dimethylarginine (ADMA), total antioxidant capacity (TAC), and hydrogen sulfide (H2S) as biomarkers of endothelial function. This study aimed to investigate any correlation between FMD and these blood biomarkers in patients with diabetes mellitus (DM), prediabetes (preDM), coronary artery disease (CAD), and valvular heart disease (VD).
Materials and Methods: Prospective evaluation was made within five groups of patients with preDM, DM, CAD, VD, and healthy controls. The FMD of the brachial artery was examined using Doppler imaging, and biomarker levels in plasma were measured by spectrophotometry.
Results: The FMD of the VD group was significantly higher than that of DM and CAD groups. Plasma NO levels of CAD and VD groups were significantly lower than those of the control group. ADMA levels were lower in the CAD group. TAC and H2S levels were comparable in all groups. The FMD of the brachial artery was negatively correlated with plasma NO and cholesterol levels in all groups.
Conclusion: These results suggested that the correlation of FMD with blood biomarkers related to endothelial function was altered in cardiovascular diseases and would be affected by the patient’s clinical state and treatment.

Keywords: Flow-mediated dilatation, endothelial function, nitric oxide, ADMA, cardiovascular diseases

Suzan Emel Usanmaz, Inci Asli Atar, Ayşen Aksöyek, Muharrem Tola, Emre Kubat, Tugba Kayhan Altuner, Hüseyin Bozbaş, Utkan Sevuk, Mehmet Emin Korkmaz, Emine Demirel-Yilmaz. Relationship Between the Flow-Mediated Dilatation of the Human Brachial Artery and Blood Biomarkers Related to the Endothelial Function in Cardiovascular Diseases. Erciyes Med J. 2021; 43(1): 75-82

Corresponding Author: Suzan Emel Usanmaz, Türkiye
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