ISSN: 2149-2247 | E-ISSN: 2149-2549
Erciyes Medical Journal Clinical Effect of Non-Dipper and Dipper Hypertension in Patients with Acute Coronary Syndrome [Erciyes Med J]
Erciyes Med J. 2021; 43(3): 282-287 | DOI: 10.14744/etd.2020.22308

Clinical Effect of Non-Dipper and Dipper Hypertension in Patients with Acute Coronary Syndrome

Deniz Elcik, Şaban Keleşoğlu, Ali Doğan, Bilge Bingol, Zeki Çetinkaya, Mehmet Tuğrul Inanç, Nihat Kalay, Ramazan Topsakal, Abdurrahman Oğuzhan
Department of Cardiology, Erciyes University Faculty of Medicine, Kayseri, Turkey

Objective: During sleep, blood pressure (BP) is generally 10%–20% lower, and the risk of target organ damage in non-dipper hypertension (HT) is related to left ventricle hypertrophy, MI, and stroke. This study aimed to analyze the effect of non-dipper HT on the prevalence of coronary artery disease (CAD), time of symptom onset, and in-hospital MACE in patients with acute coronary syndrome (ACS).
Materials and Methods: We included 107 patients who were diagnosed with ACS and had angina pectoris lasting 12 h at most and no history of CAD in this study. Patients’ ambulatory BP was monitored for 24 h. Patients were divided into the non-hipper and dipper groups according to the decrease in BP during nighttime. We compared the prevalence of CAD, time of symptom onset, and in-hospital MACE in both groups.
Results: We included 52 patients in the non-dipper group and 55 patients in the dipper group in this study. When we compared the Syntax and Gensini scores between the groups, statistical significance was determined (p=0.006). In terms of symptom onset hours, 32 (62%) and 19 (35%) patients were admitted with night angina pectoris in the non-dipper and dipper groups, respectively (p=0.007). In terms of in-hospital MACE ratios, we identified MACE in six patients in the non-dipper group and three patients in the dipper group (p=0.223).
Conclusion: In our study, we conclude that non-dipper HT increases the number of lesions, MI cases at night, and MACE ratios in CAD by causing endothelium dysfunction and stimulating thrombocyte activation.

Keywords: Acute coronary syndrome, dipper hypertension, non-dipper hypertension.

Deniz Elcik, Şaban Keleşoğlu, Ali Doğan, Bilge Bingol, Zeki Çetinkaya, Mehmet Tuğrul Inanç, Nihat Kalay, Ramazan Topsakal, Abdurrahman Oğuzhan. Clinical Effect of Non-Dipper and Dipper Hypertension in Patients with Acute Coronary Syndrome. Erciyes Med J. 2021; 43(3): 282-287

Corresponding Author: Deniz Elcik, Türkiye
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