ISSN: 2149-2247 | E-ISSN: 2149-2549
Erciyes Medical Journal High Mobility Group Box – 1 in Patients with Bacterial Septic Arthritis of the Knee: A Controlled Prospective Study [Erciyes Med J]
Erciyes Med J. 2020; 42(4): 463-467 | DOI: 10.14744/etd.2020.75299

High Mobility Group Box – 1 in Patients with Bacterial Septic Arthritis of the Knee: A Controlled Prospective Study

Alper Öztürk1, Yener Bilgetekin1, Halis Atıl Atilla1, Mesut Emlek1, Önder Ersan1, Esra Çetin2, Ali Yalçındağ2
1Department of Orthopaedics and Traumatology, University of Health Sciences, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey
2Department of Clinical Biochemistry, University of Health Sciences, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey

Objective: High mobility group Box–1 (HMGB-1) is related to inflammation and many kinds of arthritic diseases. Septic arthritis is acute infectious arthritis with potentially devastating outcomes and needs to be diagnosed and treated in an emergent manner. It is not always easy to distinguish septic arthritis from other forms of acute arthritis. In this study, we aimed to find out if serum or synovial HMGB1 can be used for diagnosis and differentiation of septic arthritis.
Materials and Methods: Consecutive patients who were admitted to the emergency department with suspected knee septic arthritis were included in this study. Patients were divided into two groups as septic and non-septic arthritis regarding Newman’s criteria. All patients underwent a laboratory analysis of serum and synovial fluid for white blood cell count, c-reactive protein, sedimentation, cultures, and HMGB1.
Results: There were 23 patients with acute bacterial septic arthritis and 21 with acute non-bacterial arthritis. No difference was observed regarding age and sex. In the septic group, serum WBC, body temperature, sedimentation, CRP and synovial WBC were significantly higher. However, no difference was observed between groups regarding serum and synovial HMGB1 levels.
Conclusion: Although HMGB1 may predict articular damage in any form of arthritis, serum or synovial HMGB1 of patients with bacterial septic arthritis are similar to patients with non-bacterial arthritis.

Keywords: HMGB1, septic arthritis, crp, orthopedic emergency.

Alper Öztürk, Yener Bilgetekin, Halis Atıl Atilla, Mesut Emlek, Önder Ersan, Esra Çetin, Ali Yalçındağ. High Mobility Group Box – 1 in Patients with Bacterial Septic Arthritis of the Knee: A Controlled Prospective Study. Erciyes Med J. 2020; 42(4): 463-467

Corresponding Author: Alper Öztürk, Türkiye
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